Sep 19, 2026
The Science of TOPK11: How We Target, TGF-β, "Burnt Out" Mitochondria and other key aspects of hair health.
Most people think hair loss is simple.
You have too much Testosterone.
It turns into DHT.
Your hair falls out.
If it were that simple, blocking DHT would cure everyone. But it doesn't.
If you want to buy a hair growth supplement that is effective, you need to understand the mechanism of action. You need to know what you are putting in your body.
Here is the deep dive into the TOPK11 formula and why we call it a "Systems Biology" solution.
Mechanism 1: The "Dual-Acting" Shield (DHT & TGF-β)
You’ve heard of DHT (Dihydrotestosterone). It shrinks hair follicles.
But DHT needs a partner to do the damage. That partner is a cytokine or signalling protein called TGF-β1 (Transforming Growth Factor Beta 1).
Think of DHT as the boss who gives the order, and TGF-β1 as the worker who actually destroys the building. When these two combine, they cause "perifollicular fibrosis". Essentially, scarring around the root that strangles the hair.
A highly impactful paper from fellow academic authors elegantly captured the role of TGF-β1 in the ecosystem of hair loss.
Source: English Jr, R.S., 2018. A hypothetical pathogenesis model for androgenic alopecia: clarifying the dihydrotestosterone paradox and rate-limiting recovery factors. Medical Hypotheses, 111, pp.73-81.
TOPK11 uses a high dose (400 mg) of Apple Extract standardized to 60% polyphenols, including procyanidin B2.
According to research published in Skin Pharmacology and Physiology, Procyanidin oligomers specifically counteract TGF-β induced apoptosis (cell death). By stopping TGF-β, we stop the scarring process that leads to permanent baldness.
We also include Soy Extract (100mg) and Fenugreek (100mg). These contain isoflavones and saponins that help lower the DHT signal without the harsh side effects of synthetic drugs.
Mechanism 2: The Metabolic Switch (Fixing the Engine)
This is where TOPK11 is different from any other hair regrowth supplement in Thailand.
Modern transcriptome profiling shows balding scalps process energy differently. They burn glucose too fast, leading to "oxidative stress". essentially, the engine is overheating.
When the mitochondria (energy centers) burn out, the hair sheds.
We utilize a metabolic approach:
Tocotrienols (Vitamin E) and Astaxanthin (80 mg): These are "super-antioxidants." Astaxanthin is up to 550 times more potent than standard Vitamin E. It protects the mitochondria from burning out.
Magnesium (83 mg): Essential for breaking down calcification (calcium buildup) that hardens the scalp and reduces blood flow.
Mechanism 3: The "Key" to Absorption (Piperine)
You can have the best hair growth supplement in the world, but if you don't absorb it, it’s useless.
Procyanidin B2 (the apple extract) is notoriously hard to absorb. It has a short "half-life," meaning your body gets rid of it quickly.
That is why we added Black Pepper Extract (5 mg).
Studies show that Piperine (the active compound in pepper) slows down "xenobiotic removal." It keeps the active ingredients in your blood longer, giving them more time to reach the hair follicle.
Summary of the Stack in TOPK11
Shield: Apple Extract & Soy (Blocks TGF-β & DHT).
Energy: Astaxanthin & Tocotrienols (Protects Mitochondria).
Foundation: Magnesium & Iron (Improves Blood Flow & Oxygen).
Delivery: Black Pepper Extract (Boosts Absorption).
This isn't magic. It's biology.
But how long does it take to see changes? Is this an overnight fix? (Spoiler: No).
Back to Post 1: The Origin Story
Stay tuned for part III
