TGF-β1 modulation
Proanthocyanidins
Statistically significant results in several modern randomised controlled trials [1,2,3] show B-type proanthocyanidins help increase hair counts, for example it helped increased hair weight by 37% over two months in a clinical trial, n=250 [1]. The proanthocyanidin targets TGF-β1 [4] which mediates perifollicular fibrosis in a high DHT/ROS environment, leading to miniaturisation [5].
SystemK11 contains the highest dose of proanthocyanidin-enriched extract on the market, in accordance with the studies. It is further enhanced with the use of piperine (BioPerine®) to increase its bioavailability.
References
Regulated hair follicle glucose metabolism
Dihydroberberine (GlucoVantage®) &
Dual fenugreek seed extracts
In 2023, high-power studies independently linked balding to sugary beverage consumption in 1,028 male participants [1] and to type 2 diabetes in 519 women in multi-variate analysis [2]. Berberine supports healthy glucose levels in meta analyses [3,4] and normalised polyol pathway activation [5], supporting energy stores in growing hair follicles [6,7]. It also increases sex-hormone binding globulin [8], a protein with high binding affinity to DHT [9] that is lowered in patients with pattern hair loss and hyperglycemia/diabetes [10]. A derivative of berberine, dihydroberberine enhances bioavailability, allowing for far lower dosages while maintaining its effectiveness [11].
Fenugreek has long been used in traditional hair loss therapy, with modern scientific corroboration in humans [12,13]. Vitexin [14] and 4-hydroxyisoleucine [15] are key components in extracts. SystemK11 also includes a galactomannan-rich fenugerek seed extract which confers a prebiotic effect and supports glucose spike regulation in digestion [16].
References
Enhanced mitochondrial protection
Ergothioneine (MitoPrime®)
L-ergothioneine, a highly potent antioxidant [1], has been clinically observed to produce significant hair health improvements [2] by directly targeting mitochondrial damage. This damage is induced by reactive oxygen species, the byproducts of unregulated aerobic respiration that contribute to the balding process [3,4], as evidenced by the oxidative stress markers found in miniaturising hair follicles compared to their non-miniaturising counterparts [5]. Its half-life of 30 days [6], coupled with its transport to mitochondria via specific proteins [7], positions l-ergothioneine as an unparalleled compound for long-term hair maintenance and protection.
While mitochondrial pyruvate carrier inhibitors are in development targeting the mitochondrial/glucose metabolism component of hair loss [8], systemK11 offers a safe, next-generation nutraceutical solution for patients today.
References
Autologous degradation of DHT facilitated
Sulforaphane glucosinolate (Activated BroccoRaphannin®)
Statistically significant outcomes in hair count have been achieved with sulforaphane in various studies [1,2], including human trials [3]. The proposed mechanism supports the expression of the enzyme 3α-hydroxysteroid dehydrogenase, which breaks down DHT into less harmful metabolites. Sulforaphane also modulates redox and has been implicated in improvements glucose metabolism [4], which associated with better hair outcomes.
Sulforaphane, due to its natural instability, is administered in systemK11 as a stable precursor called sulforaphane glucosinolate. This is paired with the myrosinase enzyme, which activates the sulforaphane at the time of delivery [4]. This method guarantees consistently high bioavailability of the active compound for the patient.
References
Hedging gently against long-term deficiencies
